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IBD and Methylation

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Emperor Penguin
Emperor Penguin

Joined: 21 Dec 2009

Posts: 7273
User's local time:
2017 Dec 15 - 2:35 PM

Food Intolerances : Gluten, Yeast, Caesin, Soy, salad/raw veges and fruit
Location: Hunter Valley NSW Australia

PostPosted: Thu May 12, 2016 3:12 pm    Post subject: IBD and Methylation Reply with quote

it is free to register for this website to see the article

(I checked to see if it has been published elsewhere on the net to make access easier but alas no)


The group's subsequent modeling analyses indicated that the combination of RNA-sequencing and genome-wide methylation data distinguished IBD from control cases with better resolution than the IBD risk variants, microbiome, expression, or methylation data alone. They also noted that DNA methylation patterns at diagnosis seemed to contain clues to disease severity.

Though Crohn's disease and ulcerative colitis are both marked by chronic, relapsing inflammation of the gut, Howell explained, the IBD conditions differ somewhat with respect to the gut region affected and the type of inflammation detected by colonoscopy. And while the conditions are known to have genetic contributors, IBD cases have been on the rise over the past few decades, she noted, highlighting the potential importance of non-genetic risk factors.

In an effort to complement past studies of the conditions which run the gamut from genome-wide association searches for IBD-associated variants to microbiome sequencing studies pointing to decreased microbial diversity in the guts of IBD-affected individuals the team focused on intestinal epithelial cells, reasoning that the cell type's role in gut function and immunity might offer particularly relevant insights into IBD pathogenesis.

Generally speaking, expression and methylation patterns often overlapped between children with Crohn's disease and ulcerative colitis when samples from the same part of the intestine were considered. On the other hand, both methylation and gene expression profiles differed depending on the site sampled, Howell explained. For example, biopsy samples collected from the ileum of children with IBD tended to show expression shifts involving components of signal transduction pathways, while immune response gene expression changes were more common in the colon.

Based on the preliminary success they've had using gene expression and DNA methylation to come up with a potential diagnostic model for IBD, the team hopes to expand its analyses to larger pediatric IBD cohorts with more biopsy samples per individual in the hopes of further improving its model and uncovering clues to other IBD features, including disease-specific biology and treatment outcomes.

based on that last paragraph, this may improve colonscopy procedures and the taking and testing of biopsies ie may help those with MC?
Gabes Ryan

"Anything that contradicts experience and logic should be abandoned"
Dalai Lama
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Site Admin
Site Admin

Joined: 24 May 2005

Posts: 30846
User's local time:
2017 Dec 14 - 10:35 PM

Food Intolerances : Gluten, casein, soy, and avenin, (avenin is the prolamin in oats, which is equivalent to the gluten in wheat), beef, grapes, peanuts, cashews, almonds, (but nut butters seem OK except for peanuts), citric acid, chocolate, and agar.
Location: Central Texas

PostPosted: Thu May 12, 2016 4:39 pm    Post subject: Reply with quote

I'll confess that I didn't register and read that article, but isn't this the original research article that article is based on? Or is this an earlier article? I had this one bookmarked for some reason or other.

DNA methylation changes in inflammatory bowel disease


It is suspected that some of the hardest material known to science can be found in the skulls of GI specialists who insist that diet has nothing to do with the treatment of microscopic colitis.
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